Replication Repair

National Institute Of Environmental Health Sciences

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Abstract

We reported previously that several mutations that abolish either of the two mechanisms of replication repair are general mutator mutations that sometimes promote templated mutations particularly strongly. Thus, defects in replication repair somehow promote template switching to an inappropriate template. We have now tested predictions about the properties of mutants carrying mutational blocks either in both pathways, or in both steps of one of the pathways. We are also testing whether DNA damage can promote templated mutagenesis.