Pathogenesis and Treatment of HIV Infection
$1,808,119Z01FY2008AINIH
National Institute Of Allergy And Infectious Diseases
Investigators
Linked publications & trials
Paper 19617815Paper 18493981Paper 18456875Paper 18448620Paper 18090390Paper 17674308Paper 17670817Paper 17596352Paper 17576678Paper 17395779Paper 17093193Paper 17068156Paper 17003402Paper 16871325Paper 16837861Paper 16731952Paper 16544259Paper 16439869Paper 16280692Paper 16136473Paper 15937547Paper 15643013Paper 15090457Paper 14645561Paper 14640722Paper 14600575Paper 14519205Paper 12794543Paper 12734009Paper 12502817Paper 12496379Paper 12370415Paper 12230939Paper 12149467Paper 11748275Paper 11579237Paper 11465092Paper 11264389Paper 11118073Paper 11106537Paper 11095734Paper 10985306Paper 10915073Paper 10623768
Abstract
IL-15 was found to be a potent inducer of FoxP3 expression in CD4+ T cells and thus be more similar to IL-2 than IL-7 in that regard. IL-2,-7 and -15 were all shown to be potent inducers of CD4 and CD8 proliferation. The cytokine induced proliferation of CD4 cells was associated with CD25 expression while the proliferation of CD8 cells was not. IL-27 was shown to, at least partially, exert its anti-HIV effects throught the induction of pathways similar to those seen with interferon alpha. Patients with idiopathic CD4 lymphopenia were noted to be a heterogeneous group of patients some of whom have immune systems characterized by immune activation.
View original record on NIH RePORTER →