Chromatin remodeling and neuronal differentiation

National Institute On Aging

Investigators

Abstract

Previously we developed conditions for EC cell differentiation to neuronal precusor cells. We identified genes that changed expression duringretinoic acid-induced differentiation to neuronal precursor cells.[unreadable] [unreadable] Progress:[unreadable] [unreadable] We found that expression of several of these genes was dependent on a remodeling enzyme.[unreadable] We found that one remodeling enzyme binds directly to the promoters of several targets.[unreadable] [unreadable] Future:[unreadable] We are interested in determining the role of remodeling enzymes in the chromatin structure of the affected loci.