IMMUNOPHILIN INTERACTIONS WITH STEROID RECEPTORS

$243,402R01FY2000DKNIH

Mayo Clinic Coll Of Med, Mayo Clinic Az, Scottsdale AZ

Investigators

Linked publications & trials

Paper 17938211 Paper 17717070 Paper 17571166 Paper 17169175 Paper 15802496 Paper 15763706 Paper 15528267 Paper 15497498 Paper 15071092 Paper 12746298 Paper 12611898 Paper 12606580 Paper 12538866 Paper 11703081 Paper 11089542 Paper 10949546 Paper 10894145 Paper 10736263

Abstract

DESCRIPTION: (adapted from applicant's abstract) The objective of this study is to determine the role of immunophilins in the regulation of steroid receptor function. The proposed research will examine structure-function correlates in the immunophilins Cyp40, FKBP51, and FKBP52 in vitro; use a yeast genetic mutant lacking the homolog of Cyp40 to test for functional complementation by human immunophilins; and examine the function of immunophilins in mammalian cell lines expressing steroid receptors.

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