Molecular Genetics Core

$212,500P30FY2008DKNIH

St. Luke'S-Roosevelt Inst For Hlth Scis, New York NY

Investigators

Linked publications & trials

Paper 39716665 Paper 39497631 Paper 39005353 Paper 38822963 Paper 38741246 Paper 38659958 Paper 38565851 Paper 38237895 Paper 37971140 Paper 37955852 Paper 37865656 Paper 37807154 Paper 37745320 Paper 37490843 Paper 37308722 Paper 36980244 Paper 36801962 Paper 36717406 Paper 36705429 Paper 36329895 Paper 36238978 Paper 36130780 Paper 36070531 Paper 35950852 Paper 35934281 Paper 35918471 Paper 35777684 Paper 35750246 Paper 35676799 Paper 35450580 Paper 35390757 Paper 35384351 Paper 35271854 Paper 35180452 Paper 34971655 Paper 34857533 Paper 34799566 Paper 34686319 Paper 34665288 Paper 34558804 Paper 34475504 Paper 34438105 Paper 34283813 Paper 34214899 Paper 34159359 Paper 33843938 Paper 33637948 Paper 33630762 Paper 33553983 Paper 33479230 Paper 33394566 Paper 33356996 Paper 33236485 Paper 33231171 Paper 32977906 Paper 32820720 Paper 32794078 Paper 32615086 Paper 32597862 Paper 32556613 Paper 32522683 Paper 32221475 Paper 32195347 Paper 32111630 Paper 32100449 Paper 32030911 Paper 31894105 Paper 31766976 Paper 31629614 Paper 31623509 Paper 31617114 Paper 31565843 Paper 31532526 Paper 31530225 Paper 31408437 Paper 31383241 Paper 31377311 Paper 31350351 Paper 31296445 Paper 31292531 Paper 31277924 Paper 31245904 Paper 31222048 Paper 31207887 Paper 31119882 Paper 31091147 Paper 31076997 Paper 31067015 Paper 31036888 Paper 30964706 Paper 30916576 Paper 30900406 Paper 30899071 Paper 30879941 Paper 30876866 Paper 30850579 Paper 30824545 Paper 30819964 Paper 30811542 Paper 30774722

Abstract

The overarching mission of the MB/MG Core is assist investigators seeking to discover the molecular bases[unreadable] underlying obesity and its comorbidities. To achieve this mission, the Core performs studies in humans and[unreadable] rodents to identify mutations in candidate genes as well as rodent studies to define the functions of[unreadable] candidate genes by genetic manipulations using transgenic methodologies, the MB/MG Core makes[unreadable] available to biomedical investigators a wide range of methodologies and reagents relevant to understanding[unreadable] me molecular physiology of obesity and energy metabolism in animals and humans. This core applies[unreadable] molecular genetic and molecular biological techniques to the mapping, cloning and functional[unreadable] characterization of genes related to obesity and its comorbidities. The services of this Core are available to[unreadable] investigators new to obesity research, as well as to investigators working on obesity-related projects that can[unreadable] be enriched and extended by the use of the expertise and facilities of this core. This Core operates in 2[unreadable] collaborating sites: Columbia University (R. Leibel) and AECOM (S. Chua). In general, techniques and[unreadable] services related to studies in humans are located at the former, and those related to rodents at tne fatter.[unreadable] However, this distinction is not rigid, and there is a lot of crossover between the sites. Services fndude a full[unreadable] range of capabilities in DNA and RNA isolation, sequencing, manipulation and quantification; experimental[unreadable] design and execution of gene/QTL-mapping studies in rodents and humans; maintenance of novel mouse[unreadable] genetic models of obesity; and design and execution of mouse transgenesis experiments.

View original record on NIH RePORTER →