CORE--IMAGING

$166,970P50FY2008DANIH

Wake Forest University Health Sciences, Winston-Salem NC

Investigators

Linked publications & trials

Paper 39527868 Paper 39251212 Paper 39161062 Paper 38860652 Paper 38760425 Paper 38597398 Paper 38508306 Paper 38499566 Paper 38370629 Paper 38142289 Paper 38039368 Paper 37703771 Paper 37699287 Paper 37118057 Paper 36724520 Paper 36507847 Paper 35897682 Paper 35461879 Paper 35385720 Paper 35141983 Paper 34385608 Paper 34265080 Paper 34116078 Paper 34040157 Paper 33660412 Paper 33631209 Paper 33315046 Paper 33301050 Paper 33261012 Paper 33025628 Paper 32730947 Paper 32725894 Paper 32541906 Paper 32479812 Paper 32473160 Paper 32468100 Paper 32239147 Paper 32236882 Paper 31941717 Paper 31726041 Paper 31705165 Paper 31366729 Paper 31111573 Paper 30747315 Paper 30416422 Paper 30284806 Paper 30252438 Paper 30158150 Paper 29454035 Paper 29203575 Paper 29175958 Paper 29056156 Paper 28942046 Paper 28826534 Paper 28750799 Paper 28736108 Paper 28666811 Paper 28493559 Paper 28376413 Paper 28286470 Paper 28139678 Paper 28059083 Paper 28025974 Paper 27966885 Paper 27936579 Paper 27899527 Paper 27895162 Paper 27886524 Paper 27528587 Paper 27480648 Paper 27466327 Paper 27394931 Paper 27393374 Paper 27267686 Paper 27255266 Paper 27233622 Paper 27124386 Paper 27059874 Paper 26964683 Paper 26860203 Paper 26690589 Paper 26625893 Paper 26525189 Paper 26523979 Paper 26500473 Paper 26321241 Paper 26037018 Paper 26011081 Paper 25749646 Paper 25724082 Paper 25689882 Paper 25684556 Paper 25673020 Paper 25630971 Paper 25553617 Paper 25491345 Paper 25474655 Paper 25446677 Paper 25446256 Paper 25421514

Abstract

The Imaging Core into the NIDA Center is intended to provide fully-integrated and comprehensive support for molecular imaging research. The Imaging Core will also include developmental components intended to provide new opportunities for pilot projects, or enhance the current capability of data acquisition by PET imaging. The coordinated elements of the Imaging Core will include positron emission tomography (PET) imaging, computer modeling, data analysis and radiochemistry. The Imaging Core will provide specialized molecular imaging tools for specific research addressed in several of the NIDA Center grant individual projects. The Core will provide a mechanism for the inclusion of several young investigators into the Center grant, as well as an infrastructure for developing future pilot projects. Moreover, the Imaging Core will allow the Center Grant to expand upon the successful development, through a previous Center funded pilot project, of the selective and high affinity dopamine transporter (DAT) radioligand, [18F]-(+)-N-(4-fluorobenzyl)- 2beta-propanoyl-3beta-(4-chlorophenyl) tropane ([18F]FCT). The Imaging Core will consist of three synergistic components: Data Analysis Component: This component will be responsible for all image data analysis, including kinetic/computer modeling, and comprehensive data and statistical analysis for Project PET scans. In addition, kinetic and computer modeling strategies will be developed for the use of new radiopharmaceuticals utilized by the projects or generated by the Imaging Core. Imaqing Component: This component will provide the necessary personnel and infrastructure to conduct the PET scans included with various Projects. The support will be comprehensive including veterinary management, PET camera technology, metabolite analysis of biological specimens, kinetic/computer modeling, data and statistical analysis, quality assurance, and assistance in manuscript, presentations, and proposals. The Imaging Component will also have a developmental component to validate and refine the quantitative techniques for MicroPET. Radiochemistry Component This component will be to carry out synthesis and production of both routine ("off-the-shelf") and custom radioligands and to make these radioligands available for both the base and pilot projects of the Center as required

View original record on NIH RePORTER →