Capital Upgrade for Adaptive SPECT Imaging System

$265,730P41FY2008EBNIH

University Of Arizona, Tucson AZ

Investigators

Linked publications, trials & patents

Paper 38255712 Paper 38160623 Paper 36686276 Paper 36270074 Paper 34845659 Paper 34665280 Paper 34390587 Paper 33690468 Paper 33313340 Paper 32235062 Paper 32118929 Paper 31503959 Paper 31470417 Paper 31111961 Paper 30820441 Paper 30772168 Paper 29958271 Paper 29930991 Paper 29635734 Paper 29276799 Paper 29207127 Paper 29150683 Paper 28370094 Paper 27574992 Paper 27505644 Paper 27478293 Paper 27236285 Paper 27175376 Paper 27103751 Paper 27066595 Paper 27019577 Paper 26974897 Paper 26937167 Paper 26855557 Paper 26801880 Paper 26778914 Paper 26778913 Paper 26778912 Paper 26778911 Paper 26644631 Paper 26635419 Paper 26617458 Paper 26617457 Paper 26617422 Paper 26568677 Paper 26568676 Paper 26568675 Paper 26568674 Paper 26568673 Paper 26568672 Paper 26568671 Paper 26538684 Paper 26523069 Paper 26430291 Paper 26388686 Paper 26367158 Paper 26366764 Paper 26366028 Paper 26350439 Paper 26347497 Paper 26347396 Paper 26347393 Paper 26347197 Paper 26347027 Paper 26346933 Paper 26346820 Paper 26346707 Paper 26346627 Paper 26346619 Paper 26346514 Paper 26346410 Paper 26345126 Paper 26339114 Paper 26338894 Paper 26316682 Paper 26247228 Paper 26236070 Paper 26236069 Paper 26236068 Paper 26236067 Paper 26236041 Paper 26236040 Paper 26204937 Paper 26190885 Paper 26190884 Paper 26166931 Paper 26166921 Paper 26160984 Paper 26160983 Paper 26146444 Paper 26146443 Paper 26133610 Paper 25564960 Paper 25242901 Paper 25195016 Paper 24216862 Patent 9977136 Patent 9823364 Patent 8519338 Patent 7928397

Abstract

[unreadable] DESCRIPTION (provided by applicant): The Center for Gamma-Ray Imaging (CGRI) is an NIBIB-funded biotechnology-development resource whose scope includes the development of advanced gamma-ray detectors and imaging systems, the development and application of tools for the objective assessment of image quality and for system optimization, and the application of these imaging systems to important biological problems via internal and collaborative research and service to the biomedical community. This application is for a Competing Supplement, now called a Revision, for instrument upgrades to CGRI's flagship FastSPECT II imager in order to implement the new concept of adaptive imaging. In recent work, we have investigated the concept of adapting the imager configuration to optimize image quality for a particular imaging subject rather than a population of subjects. This involves acquiring and analyzing preliminary scout data and making automated decisions for setting the adjustable parameters in the system. We have completed a prototype single-camera adaptive SPECT system, we have developed a theoretical framework for the computations required to adapt a system optimally to a particular subject and task, and we have analyzed the benefits of creating feedback rules that involve data from a complementary modality such as X-ray computed tomography (CT). These preliminary studies have led us to the conclusion that adaptive SPECT represents a significant advance in molecular imaging that will have impact in both laboratory and clinical settings. Our specific request in this supplemental proposal is for capital upgrades that replace the 16 fixed modular gamma cameras in the FastSPECT II system with a full complement of updated and radially translatable cameras, and for the fabrication and motorization of a matching adjustable aperture assembly. The development of adaptive small-animal SPECT is a specific aim in the Center for Gamma-Ray Imaging's on-going funding, and increasing the scope of the project to include implementation on one of the Center's most utilized systems will provide opportunities for demonstrating the benefits of adaptive imaging in cancer, cardiac disease, and neuroimaging. [unreadable] [unreadable] [unreadable]

View original record on NIH RePORTER →