REGULATION OF CYCLIN D1 EXPRESSION

$339,188R01FY2000CANIH

Yeshiva University, New York NY

Investigators

Linked publications & trials

Paper 30718920 Paper 29721077 Paper 29358169 Paper 29137220 Paper 28522753 Paper 28045030 Paper 27634768 Paper 26967564 Paper 26820950 Paper 26582866 Paper 26323205 Paper 25940700 Paper 25769723 Paper 25545407 Paper 25529796 Paper 25452256 Paper 25256399 Paper 25229978 Paper 24886939 Paper 24846069 Paper 24830723 Paper 24658544 Paper 24387133 Paper 24335958 Paper 24287487 Paper 24282282 Paper 24240682 Paper 23864650 Paper 23798621 Paper 23636126 Paper 23492369 Paper 23262432 Paper 23204233 Paper 22981632 Paper 22935696 Paper 22918248 Paper 22894905 Paper 22878233 Paper 22874531 Paper 22722266 Paper 22684333 Paper 22684298 Paper 22637726 Paper 22395432 Paper 22382486 Paper 22313602 Paper 22307325 Paper 22249027 Paper 22236876 Paper 22236875 Paper 22234241 Paper 22174367 Paper 22134189 Paper 22129993 Paper 22077552 Paper 22041887 Paper 22041584 Paper 22033146 Paper 21990314 Paper 21883043 Paper 21867571 Paper 21796527 Paper 21778829 Paper 21768775 Paper 21734470 Paper 21675838 Paper 21654190 Paper 21646868 Paper 21640330 Paper 21566463 Paper 21558814 Paper 21512313 Paper 21447400 Paper 21300172 Paper 21220498 Paper 21200149 Paper 21189328 Paper 21167281 Paper 21159656 Paper 21150282 Paper 21051947 Paper 20956529 Paper 20940395 Paper 20937839 Paper 20926681 Paper 20864819 Paper 20861672 Paper 20861671 Paper 20855962 Paper 20818174 Paper 20814239 Paper 20562527 Paper 20562526 Paper 20519932 Paper 20495363 Paper 20443831 Paper 20442453 Paper 20406904 Paper 20351289 Paper 20179208

Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract) The proposed studies will: 1. Determine the mechanisms regulating cyclin D1 transcription and activity by transactivators/co-regulators using cultured cells, inducible lines, and transgenic mice, and identify the target DNA sequence required for regulation of the cycin D1 gene. 2. The requirement for cyclin D1 transformation by Neu and b-catenin/APC will be evaluated using anti-sense techniques, transgenic and knockout mice. The requirement for cyclin D1 in b-catenin/APC induced tumorigenesis will be determined. The requirement for c-Jun/cyclin D1 in mammary oncogenesis will be tested using inducible knockout gene technology.

View original record on NIH RePORTER →