IP10 CHEMOKINE--ITS ROLE IN T CELL RECRUITMENT &DISEASE

$395,285R01FY2000CANIH

Massachusetts General Hospital, Boston MA

Investigators

Linked publications & trials

Paper 27795366 Paper 26109379 Paper 26067148 Paper 25480554 Paper 25049334 Paper 24812325 Paper 24043884 Paper 24017968 Paper 23967339 Paper 23580465 Paper 23255361 Paper 23144331 Paper 23123063 Paper 22990625 Paper 22980984 Paper 22722867 Paper 21624939 Paper 21555535 Paper 21376175 Paper 21221121 Paper 20932719 Paper 20856926 Paper 20828409 Paper 20811054 Paper 20484822 Paper 19797174 Paper 19494319 Paper 19480929 Paper 19139386 Paper 19039768 Paper 18347328 Paper 18337479 Paper 18206159 Paper 18171218 Paper 18066075 Paper 18003726 Paper 17606602 Paper 17553894 Paper 17082614 Paper 17056513 Paper 16847335 Paper 16789839 Paper 16303787 Paper 16116313 Paper 16103196 Paper 15668740 Paper 15205180 Paper 15150261 Paper 14707046 Paper 14660742 Paper 12949531 Paper 12928408 Paper 12829592 Paper 12737818 Paper 12571234 Paper 12133984 Paper 11994485 Paper 11907073 Paper 11907072 Paper 11739530 Paper 11500837 Paper 11390519 Paper 11359856 Paper 11086100 Paper 11015448 Paper 10934232 Paper 10843708 Paper 10843381 Paper 10666407

Abstract

DESCRIPTION: (Adapted from the applicant's abstract) In this competing renewal application Dr. Luster proposes to study the role of the chemokine IP-10 in T cell recruitment and disease. The first aim is to determine the structural domains on IP-10 that mediate its chemotactic effects on T cells, as well as its anti-proliferative effects on endothelial cells. Solving the crystal structure of IP-10 is part of this aim. The second aim is to determine the roles of IP-10 and CXCR3 in murine models of inflammation and infection. Both IP-10 and CXCR3 knockout mice will be used in these studies. The third aim is to correlate the expression of IP-10 with the infiltration of CXCR3+ T cells in tissues isolated from patients with several selected diseases.

View original record on NIH RePORTER →