HIV RESISTANCE AND RECOMBINATION IN SCID-HU MICE

University Of Alabama At Birmingham, Birmingham AL

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Linked publications & trials

Abstract

DESCRIPTION: The proposed studies will examine the biological consequences of multiple resistance mutations on viral replication and pathogenicity, using the SCID-hu mouse system. This system will be used to test the hypothesis that multiply resistant strains of HIV are less evolutionarily fit. In addition, the effect of antiviral selective pressure and/or mutations in reverse transcriptase on viral recombination will be studied in vivo.