Studies of Alpha-tocopherol and Beta-Carotene in Finland

$2,072,976Z01FY2007CANIH

Cancer Epidemiology And Genetics

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Paper 22232734 Paper 21784952 Paper 21540233 Paper 18546266 Paper 18349272 Paper 17548707 Paper 17548693 Paper 17416782 Paper 17278090 Paper 17265529 Paper 17119043 Paper 17093175 Paper 17047193 Paper 17047087 Paper 17035415 Paper 17023722 Paper 16877536

Abstract

Male smokers between the ages of 50 and 69 were recruited from southwestern Finland between April 1985 and June 1988. A total of 29,133 men were randomly assigned to one of four intervention groups: 50 mg/day a-tocopherol (as dl-a-tocopheryl acetate); 20 mg/day b-carotene; both a-tocopherol and b-carotene; or placebo. They were followed for five to eight years during the trial, until death, or 30 April 1993 when intervention was stopped (median follow-up, 6.1 years). Follow-up for endpoints was continued postintervention.

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