Amyloid-like interactions in fungal cell adhesion
$182,912S06FY2007GMNIH
Brooklyn College, New York NY
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Abstract
Summary: We are discovering that amyloids have key roles in pathogenic adhesion of fungi. Amyloid properties emerge from studies of a model peptide based on a sequence in the C. albicans adhesion AlsSp. This amyloid-like interaction is associated with formation of fungal and mixed fungal-bacterial biofilms. We have 3 papers published, 1 in press, 3 submitted, and 3 in preparation.
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