Washington University Center for Translational Neuroscience

$239,025P30FY2007NSNIH

Washington University, Saint Louis MO

Investigators

Linked publications & trials

Paper 37516908 Paper 37071533 Paper 36944081 Paper 36778242 Paper 34623323 Paper 34191802 Paper 33719573 Paper 32710817 Paper 32434080 Paper 32036385 Paper 31632407 Paper 31085199 Paper 30576626 Paper 30175957 Paper 29123109 Paper 29109678 Paper 29094110 Paper 28831103 Paper 28734986 Paper 28708061 Paper 28481001 Paper 28423317 Paper 28380694 Paper 28365421 Paper 28123067 Paper 27514643 Paper 27297909 Paper 27210553 Paper 27208617 Paper 27104893 Paper 26859681 Paper 26725834 Paper 26693175 Paper 26644583 Paper 26631553 Paper 26550774 Paper 26481044 Paper 26466815 Paper 26412387 Paper 26405204 Paper 26350769 Paper 26344756 Paper 26335648 Paper 26212712 Paper 26134120 Paper 25926453 Paper 25925892 Paper 25913403 Paper 25871773 Paper 25788518 Paper 25681442 Paper 25634895 Paper 25630890 Paper 25550197 Paper 25549850 Paper 25422493 Paper 25326002 Paper 25261551 Paper 25253864 Paper 25252943 Paper 25142573 Paper 25093726 Paper 25083989 Paper 24898927 Paper 24857020 Paper 24789352 Paper 24728940 Paper 24711582 Paper 24598588 Paper 24595139 Paper 24443954 Paper 24319330 Paper 24270424 Paper 24259665 Paper 24244744 Paper 24212387 Paper 24155314 Paper 24151192 Paper 24145067 Paper 24131187 Paper 24107946 Paper 24058581 Paper 24049115 Paper 24017967 Paper 24012374 Paper 24006512 Paper 23967090 Paper 23966672 Paper 23962724 Paper 23946820 Paper 23918930 Paper 23904623 Paper 23898162 Paper 23892229 Paper 23787819 Paper 23763461 Paper 23762458 Paper 23750121 Paper 23734233 Paper 23700471

Abstract

A Molecular Analysis Core is proposed for providing basic and clinical researchers with consultation and[unreadable] expertise in genomics and proteomics technology, experimental design, and data interpretation for[unreadable] translational studies in diseases of the nervous system. Facilitated access to the Affymetrix GeneChip[unreadable] microarray platform for performing gene expression analysis and array-based 'whole genome' SNP[unreadable] genotyping, the Sequenom technology platform for performing targeted genotyping on large numbers of[unreadable] samples, and candidate gene capillary resequencing for mutational profiling studies will be provided.[unreadable] Neuroscience investigators will have preferred access to current and innovative proteomics technology.[unreadable] These will include instrumentation and methods for the separation of complex protein mixtures, robotics for[unreadable] sample processing, and protein identification and characterization (e.g. covalent modifications) using 'state-of-[unreadable] the-art' tandem mass spectrometry coupled to automated multi-dimensional capillary liquid[unreadable] chromatographs. Proposed neuroproteomic themes will be discovery and validation of protein biomarkers,[unreadable] measuring in vivo metabolic half- lives of disease-associated proteins in humans, defining functional protein[unreadable] modifications on receptors and ion channels, and characterizing novel protein complexes. Investigators will[unreadable] have facilitated access to genomics and proteomics data both within Core C and through the coordinated,[unreadable] interdisciplinary activities of the Administrative Core A. Statistical evaluation, data management and[unreadable] integration will be provided with the proposed Informatics Core G. The application of these new technologies[unreadable] to diseases of the nervous system promises to revolutionize our understanding of these disorders and will[unreadable] help turn basic neurobiological discovery into diagnostic and therapeutic advances.

View original record on NIH RePORTER →