PHARMACOLOGICAL CORRELATES OF AGING AND BRAIN CELL GRAFTS

$233,222P01FY2007AGNIH

University Of South Florida, Tampa FL

Investigators

Ann-Charlotte Esther Granholm-Bentleycontact

Linked publications & trials

Paper 28299644 Paper 28163132 Paper 24381292 Paper 24323276 Paper 23965628 Paper 23481567 Paper 23263793 Paper 23171029 Paper 23077045 Paper 22198698 Paper 22143245 Paper 22108721 Paper 22072675 Paper 21961084 Paper 21593991 Paper 21535919 Paper 21534956 Paper 21396159 Paper 21297896 Paper 21273420 Paper 21266082 Paper 21158978 Paper 21041631 Paper 20951738 Paper 20660248 Paper 20586644 Paper 20551899 Paper 20463965 Paper 20018408 Paper 20014277 Paper 19900216 Paper 19595818 Paper 19424850 Paper 19399894 Paper 19369565 Paper 19275633 Paper 19215301 Paper 19150447 Paper 19096159 Paper 19041929 Paper 18946741 Paper 18809505 Paper 18789000 Paper 18665160 Paper 18513144 Paper 18482714 Paper 18478117 Paper 18457818 Paper 18410522 Paper 18312851 Paper 18285804 Paper 18275610 Paper 18055209 Paper 18001276 Paper 17561174 Paper 17503733 Paper 17445801 Paper 17292337 Paper 17182181 Paper 17084014 Paper 16488025 Paper 16257472 Paper 16176814 Paper 16175569 Paper 16137678 Paper 15950320 Paper 15929556 Paper 15857673 Paper 15817266 Paper 15789659 Paper 15537737 Paper 15468085 Paper 15371745 Paper 15217386 Paper 15212841 Paper 15123337 Paper 14674857 Paper 14622128 Paper 14568305 Paper 12782002 Paper 12657457 Paper 12650994 Paper 12642175 Paper 12591156 Paper 12527443 Paper 12431416 Paper 12425941 Paper 12419414 Paper 12395091 Paper 12123857 Paper 12122072 Paper 12122042 Paper 11814559 Paper 11740502 Paper 11514987 Paper 11514986 Paper 11476591 Paper 11438851 Paper 11270555 Paper 11181830

Abstract

Project 4 aims to explore age-related neurodegeneration from the perspective of one particular neuronal[unreadable] population, namely the locus coeruleus noradrenergic (LC-NE) neurons. This neuronal population[unreadable] deteriorates in the brain during normal aging but also in the brain of Alzheimer's and Parkinson's disease[unreadable] patients. The activity of LC-NE neurons may act as an endogenous protection against insults such as[unreadable] neuroinflammation and oxidative stress. Therefore this project aims to study the role of locus coeruleus in[unreadable] maintaining the overall health of the limbic system and the nigrostriatal system during aging. Since intrinsic[unreadable] vs. extrinsic factors influencing neurodegeneration are difficult to delineate in the intact animal, we propose[unreadable] to utilize intraocular transplants consisting of LC-NE neurons in combination with hippocampal and midbrain[unreadable] nigra dopamine neurons, to examine the specific function of these neurons in aging and age-related[unreadable] neurodegeneration. Intrinsic vs. extrinsic factors will also be examined with blueberry diets (BB) in[unreadable] collaboration with Project 1, to explore the mechanism for its neuroprotective properties. We propose the[unreadable] following two hypotheses for Project 4: 1) LC-NE neurons play a role in protecting other brain regions from[unreadable] oxidative stress and/or inflammation, and age-related degeneration of these neurons leads to secondary[unreadable] damage in the hippocampus, and the midbrain nigra region. 2) Treatment with blueberry extract can reverse[unreadable] age-related degeneration of the LC-NE system, and improve graft survival into the aged host.[unreadable] Based on these hypotheses, we have formulated three aims in which we will explore the relationship[unreadable] between LC-NE innervation and age-related inflammatory and oxidative stress markers. Project 4 will[unreadable] collaborate with Project 1 in terms of blueberry studies, with Project 2 in terms of microglial markers, with[unreadable] Project 3 in terms of the M1/M2 specific markers, and with Project 5 in terms of comparison of protein levels[unreadable] with mRNA expression for critical markers of neurodegeneration with aging.[unreadable]

View original record on NIH RePORTER →