IMMUNOPATHOGENESIS OF MYCOBACTERIUM &SIV COINFECTION IN MACAQUES

$96,192P51FY2000RRNIH

Harvard University (Medical School), Boston MA

Investigators

Linked publications & trials

Paper 36366153 Paper 33657166 Paper 32393800 Paper 32001079 Paper 30652349 Paper 30502901 Paper 29720564 Paper 29635114 Paper 29496145 Paper 29460723 Paper 29344862 Paper 29256819 Paper 28973854 Paper 28792003 Paper 28747495 Paper 28671063 Paper 28228258 Paper 28170189 Paper 27683750 Paper 27559102 Paper 27544476 Paper 27435105 Paper 26596587 Paper 26585218 Paper 26185285 Paper 26129855 Paper 25915761 Paper 25877746 Paper 25732245 Paper 25732063 Paper 25707797 Paper 25688559 Paper 25479017 Paper 25468404 Paper 25308086 Paper 25282469 Paper 25143442 Paper 25135832 Paper 25011105 Paper 25010769 Paper 24899503 Paper 24702501 Paper 24628518 Paper 24489878 Paper 24447378 Paper 24416083 Paper 24411773 Paper 24399297 Paper 24335292 Paper 24330519 Paper 24172905 Paper 24163808 Paper 24109219 Paper 24098278 Paper 24069471 Paper 24056786 Paper 24027336 Paper 23737549 Paper 23725361 Paper 23723737 Paper 23696734 Paper 23666606 Paper 23637396 Paper 23615116 Paper 23588085 Paper 23527882 Paper 23499489 Paper 23483986 Paper 23472105 Paper 23459687 Paper 23403573 Paper 23357301 Paper 23354533 Paper 23303046 Paper 23300447 Paper 23290931 Paper 23280047 Paper 23269489 Paper 23256740 Paper 23211411 Paper 23209422 Paper 23185133 Paper 23154262 Paper 23152518 Paper 23135296 Paper 23126673 Paper 23099234 Paper 23085363 Paper 23051916 Paper 23028326 Paper 22993152 Paper 22969429 Paper 22948980 Paper 22933282 Paper 22927823 Paper 22815535 Paper 22778226 Paper 22734618 Paper 22711907 Paper 22653975

Abstract

Coinfection with HIV and Mycobacterium tuberculosis is associated with high rates of active tuberculosis and possibly an acceleration of the progression to clinical AIDS Elucidating the interplay of the immunopathogenic events that occur as a result of HIV/M tuberculosis coinfection is, therefore, of central importance for understanding the immune sequelae of this coinfection We have shown that macaques coinfected with SIV and Mycobacterium bovis Bacille Calmette-Guerin (BCG) develop a syndrome similar to AIDS-related tuberculosis Using this SIV/BCG coinfection model, we plan to study the immunopathogenesis of AIDS virus interactions with mycobacteria and the evolution of tuberculosis Publication Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW In vivo effects of a bacterial superantigen on macaque TCR repertoires J Immunol, 160:5170-5180, 1998

View original record on NIH RePORTER →