SYNTHESIS &BIOLOGICAL ACTIVITY OF NOVEL TRITERPENOIDS

$1,840P41FY2000RRNIH

Boston University Medical Campus, Boston MA

Investigators

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Abstract

A component or mixture of component has been obtained from a plant source. The apparently small molecule(s), whose N1W is below 1000 Da, showed anti-integrase activity andmay have potential as a retroviral agent. The material has UV absorptivity and is highly fluorescent; these properties are being utilized to guide purification. MALDI-TOF MS is being used to characterize samples purified on thin layer chromatographic plates.

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