IMAGING OF ARTICULAR CARTILAGE FOR OSTEOARTHR

$28,012P41FY2000RRNIH

University Of Pennsylvania, Philadelphia PA

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Abstract

Proton T1r dispersion imaging holds great promise as a method of measuring and imaging 17O concentrations. However, careful choice of pulse sequence parameters is crucial to its proper operation. In particular, the choices of spin-locking times and spin-locking powers are of utmost importance in maximizing the sensitivity and specificity for 17O. We have begun to use a "propagation of error" analysis to determine the optimum spin-locking powers and times for tissues of varying relaxation properties and 17O concentrations. The results of our mathematical modelling will be verified with in vitro and in vivo experiments.

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