KINETIC ANALYSIS OF DNA &PROTEIN INTERACTIONS

$7,662P41FY2000RRNIH

University Of Calif-Los Alamos Nat Lab, Los Alamos NM

Investigators

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Abstract

A new method has been developed to study the interactions of DNA repair enzymes with fluorescent oligonucleotides bound to beads. We have identified important regions in the human flap endonuclease responsible for binding and enzymatic activity (Shen et al., JBC, 1996). We are developing a detailed analysis of enzyme activity on particles for single turnover kinetics (Nolan et al., Biochemistry, 1996).

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