IRRADIATION INDUCED G2 &M PHASE ARREST IN RAD SENSITIVE &RESISTANT MOUSE CELLS

$1,532P41FY2000RRNIH

University Of Calif-Los Alamos Nat Lab, Los Alamos NM

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Abstract

Flow cytometric analyses of continuous BrdU incorporation patterns are being performed on radiation-sensitive and radiation-resistant lines of mouse cells at periods up to 24 h following doses of gamma radiation. These studies are designed to determine the extent of the sensitivity of the mouse cell lines following the transfection of new genes into the parental cell line. We have recently demonstrated that the transfection of specific genes can increase the radiation sensitivity of some cell line at different phases in the cell cycle.

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