LIGHT DARK PHENOMENON OBSERVED IN DAUGHTER CELLS: GENOMICS

$1,532P41FY2000RRNIH

University Of Calif-Los Alamos Nat Lab, Los Alamos NM

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Abstract

Dr. Donndelinger and coworker have observed an interesting phenomena in high resolution microscopy of thin tissue sections 'light' and 'dark' cells in the sections. There appears to be some degree or regularity in the occurrence of the two types of cells, with obvious differences in daughter cells where one is light and the mate is dark. We are exploring whether it is feasible to flow sort "light" from "dark" cells with the goal of determining whether there are any genetic differences between the two types. As a first step, we sent him a sample of fixed multicellular spheroids that he is examining to see of the phenomenon is present. It appears that the light/dark phenomena does not occur in dividing spheroid cells. No other model suitable for sorting system has been proposed.

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