STUDIES OF THE DNA REPLICATION PROCESS

$8,199P41FY2000RRNIH

Rockefeller University, New York NY

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Abstract

The 10-subunit replicase of Ecoli has two DNA polymerases for the two strands of duplex DNA. These enzymes are tethered to DNA by a sliding clamp protein that completely encircles DNA. A five-protein "clamp loader" uses ATP to open and close the protein ring around DNA. We are currently trying to characterize the molecular mechanism of the novel clamp loader complex.

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