X-RAY CRYSTALLOGRAPHIC AND BIOCHEMICAL STUDIES OF DCP1DECAPPING ENZYME.

$8,199P41FY2000RRNIH

Rockefeller University, New York NY

Investigators

Linked publications & trials

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Abstract

DCP I is a newly characterized yeast phosphatase that is believed to play a role in the removal of the 5' 7-methyl-Guanine cap of mRNA to allow for efficient mRNA degradation. Structural and biochemical studies are being undertaken on this enzyme. MALDI-MS is used to map limited digests of the protein to elucidate the folding domains of the protein and determine useful constructs for growing protein crystals sufficient for high resolution X-ray crystallographic studies.

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