MAPPING THE INTERACTIONS OF RECA WITH DNA

$8,199P41FY2000RRNIH

Rockefeller University, New York NY

Investigators

Linked publications & trials

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Abstract

The Adzuma Laboratory is making an effort to understand the mechanisms of DNA recombination reactions. Their efforts are focused on the homologous recombination reaction catalyzed by RecA. MALDI-ion trap mass spectrometry was used to confirm a binding site of single stranded DNA on E. Coli RecA using photo-crosslinking. A paper describing analytical aspects of the determination of the site of crosslinking (Qin and Chait, Anal. Chem. 69,4002-4009, 1997).

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