SOLID PHASE SYNTHESIS OF PEPTIDES &PROTEINS

$8,199P41FY2000RRNIH

Rockefeller University, New York NY

Investigators

Linked publications & trials

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Abstract

We are using solid Phase Synthesis to produce varied hybrid analogs of antibiotic peptides, utilizing D & L amino acids for the purpose of (I) Potentiating the antibiotic effect (II) Decreasing the susceptibility of these peptides to circulating peptidase digestion. (III) Elucidating the nature of the peptide-cell wall & peptide-peptide interactions.

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