Design Of Immunogens

Niaid Extramural Activities

Investigators

Linked publications & trials

Abstract

Based on our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised scaffolding technology, as a means of presenting structural mimics of the epitopes of broadly neutralizing antibodies to assist in their re-elicitation.