Crystallographic Studies of Chemokines, Chemokine Recept

Clinical Sciences

Investigators

Linked publications & trials

Abstract

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines and defensins in the process of viral infection. We are also interested in correlating the structures of defensins and chemokines with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of human L-asparaginase and plant-type asparaginases, structures of urokinase plasminogen activator complex with its receptor as wel as TREM-Like Transcript protein 1 (TLT-1). Although we primarily use X-ray crystallography in our studies, our research techniques extend into biochemistry and molecular biology.