CORE--TOXICOLOGY AND FORMULATION CORE

$104,534P01FY2000DANIH

University Of Arizona, Tucson AZ

Investigators

Linked publications & trials

Paper 34798381 Paper 34072734 Paper 33781493 Paper 29858157 Paper 29679901 Paper 28832395 Paper 28819330 Paper 28715181 Paper 28485408 Paper 27797517 Paper 27756562 Paper 27619237 Paper 27203574 Paper 27117332 Paper 26824470 Paper 26712115 Paper 26611918 Paper 26465170 Paper 26323872 Paper 26316468 Paper 26299827 Paper 26221618 Paper 26218460 Paper 26212775 Paper 25703306 Paper 25434001 Paper 25282551 Paper 24937046 Paper 24742335 Paper 24635521 Paper 24084045 Paper 23969300 Paper 23899615 Paper 23860305 Paper 23623418 Paper 23616095 Paper 23424488 Paper 23276279 Paper 22724132 Paper 22394120 Paper 22285397 Paper 22283513 Paper 21928837 Paper 21925887 Paper 21571003 Paper 21550594 Paper 21486697 Paper 21366266 Paper 21354865 Paper 21208601 Paper 21128594 Paper 21036224 Paper 20977451 Paper 20924622 Paper 20826131 Paper 20727859 Paper 20718739 Paper 20692738 Paper 20688117 Paper 20617791 Paper 20560643 Paper 20547453 Paper 20496895 Paper 20476738 Paper 20021440 Paper 20000552 Paper 19996949 Paper 19879656 Paper 19762245 Paper 19560919 Paper 19540763 Paper 19491327 Paper 19454250 Paper 19400302 Paper 19400292 Paper 19400153 Paper 19340283 Paper 18976961 Paper 18702500 Paper 18502541 Paper 18450375 Paper 18423417 Paper 18412316 Paper 18266313 Paper 18162180 Paper 18088090 Paper 17927164 Paper 17869585 Paper 17760455 Paper 17710225 Paper 17657709 Paper 17539621 Paper 17516639 Paper 17482720 Paper 17329100 Paper 17322005 Paper 17314042 Paper 17268578 Paper 17203138 Paper 17201419

Abstract

The overall goal of this Core Facility is to perform preclinical toxicological studies on two potent delta opioid receptor antagonists c[D-Pen2,D-Pen5]enkephalin (DPDPE) and biphalin, to prepare sterile pyrogen free injectable DPDPE and biphalin solution for preclinical toxicological studies at The University of Arizona and by Dr. Yaksh at the University of San Diego. Specifically, we will perform intravenous acute toxicology studies for DPDPE and biphalin in rats and dogs giving daily i.v. injections of either agent or 30 and 5 days, respectively. At the end of dosing the animals will be euthanized and organs will be collected, weighed and tissue slices prepared for blinded histopathological studies. If not toxic, the data from these studies will be combined with the I.T. toxicological studies of Dr. Yaksh and incorporated into an investigator-sponsored investigational New Drug Application (INDA) for each agent.

View original record on NIH RePORTER →