PROJECT II - IGM-BINDING EPITOPES IN INJURED TISSUE
$165,000P50FY2005GMNIH
Brigham And Women'S Hospital, Boston MA
Investigators
Linked publications & trials
Paper 27801682Paper 27086922Paper 25291985Paper 24928991Paper 24523504Paper 23596057Paper 22840841Paper 22094766Paper 21076070Paper 20462867Paper 20335374Paper 19628094Paper 19106810Paper 17114482Paper 16982912Paper 16876247Paper 16781728Paper 16455333Paper 16390934Paper 15905575Paper 15522315Paper 15522311Paper 15300207Paper 15159059Paper 14648724Paper 12578725Paper 12219031Paper 11990934Paper 11988665Paper 11934669Paper 11704546Paper 11500303Paper 11412252Paper 11174714Paper 11146788Paper 11131910Paper 10923012Paper 10913019Paper 10792960
Abstract
Project II seeks to develop the finding that a single clone of murine IgM is pathogenic for intestinal reperfusion injury in antibody-deficient animals. The first aim will be to determine whether this antibody binds to definable antigens in murine tissue, whether injured or not. This investigation may lead to discovery of the identity of the murine antigen. In parallel, studies of human peritoneal B lymphocytes will be initiated in an attempt to determine whether the products of these cells have activity which is similar to the activity of the monoclonal IgM. Finally, support with histochemistry and complement assays will be given to other Projects within the Trauma Center.
View original record on NIH RePORTER →