Identification of the gene causing leiomyoma

$0M01FY2000RRNIH

Children'S Hospital Med Ctr (Cincinnati), Cincinnati OH

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Abstract

Leiomyoma is a benign tumor of smooth muscle which occurs most frequently in the uterus and is diagnosed in 20 to 50% of women of reproductive age. Approximately 20% of uterine leiomyomas (ULs) show a recurrent chromosomal translocation which is often the sole detectable cytogenetic aberration, suggesting that it may represent an early event in the pathogenesis of leiomyoma.

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