Urea kinetic modeling in pediatric hemodialysis patients

$0M01FY2000RRNIH

Children'S Hospital Med Ctr (Cincinnati), Cincinnati OH

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Abstract

Urea kinetic modeling has become the standard by which dialysis dose is measured. Accurate calculation requires measuring residual renal function (24-48 hour urine), which is difficult in small children and clearance by the dialysis procedure. Dialysis clearance is dependent on determining the amount of urea removed. The hypothesis is that a predictive mathematical model can be developed that would obviate the need for collection of urine to determine residual function and would take into account urea rebound. Such a model would result in a more accurate measure of dialysis "dose" in children.

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