EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL

$38,800M01FY2000RRNIH

Wake Forest University, Winston Salem NC

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Abstract

Apolipoprotein A-IV is a lipid binding protein found in the intestine, which plays a role in the absorption of dietary fat. A genetic variation, apo A-IV-2, has been found to affect how much dietary cholesterol changes cholesterol in the blood. We studied two groups of subjects, one group which carried the genetic variation, A-IV-2, which can affect dietary cholesterol absorption, and a normal control group, to determine how rapidly they could metabolize fat.

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