Peptide &APC based melanoma vaccine

$0M01FY2000RRNIH

University Of Connecticut Sch Of Med/Dnt, Farmington CT

Investigators

Linked publications & trials

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Abstract

This protocol extends the previous monocyte-based vaccine therapy by using autologous monocytes cultured in vitro to differentiate into dendrite cells, and pulsing them with synthetic MAGE or MART peptides. In addition, patients receive low-dose cyclophosphamide to decrease suppressor cell activity and intravenous IL-12 to increase the ability of the dendrite cells to present antigen.

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