MECHANISMS OF GLUCOSE INTOLERANCE IN CHILDREN WITH IDDM

$25,789M01FY2000RRNIH

Yale University, New Haven CT

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Abstract

The euglycemic, hyperinsulinemic and hyperglycemic clamp techniques are being employed to determine the effects of age and developmental stage on insulin sensitivity and insulin secretion in childhood health and disease. Currently, the hyperglycemic clamp and oral glucose is being utilized to assess effects of gut factors on insulin responses to glucose.

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