AUTOIMMUNE MECHANISMS IN PEDIATRIC NEUROPSYCHIATRIC DISORDERS
$128,106M01FY2000RRNIH
Weill Medical College Of Cornell Univ, New York NY
Investigators
Linked publications & trials
Paper 22292110Paper 20977343Paper 19906219Paper 19391080Paper 19017985Paper 18097152Paper 17316097Paper 17079285Paper 16763388Paper 16339698Paper 15526720Paper 15270860Paper 14962217Paper 14703595Paper 14625263Paper 14581545Paper 12654942Paper 12525204Paper 12468338Paper 12442030Paper 12393516Paper 12027270Paper 11967296Paper 11880731Paper 11821496Paper 11781358Paper 11605171Paper 11391167Paper 11335777Paper 11335753Paper 11170984Paper 11135346Paper 11085758Paper 11075607Paper 10912545Paper 10880061Paper 10807191Paper 10783035
Abstract
Recent evidence suggests that Sydenham chorea, obsessive/compulsive disorder and Tourette syndrome may have a similar autoimmune basis. Dr. Zabriskie and co-workers have shown that a specific B-cell D8/17 clonal marker is greatly expanded in all of these groups. The goal of the present study is to correlate brain autoantigens, B-cell clonal status and neurologic, psychaitric and cognitive outcome in all of these groups. If correlations are found, efforts will be made to isolate the respective autoantigens.
View original record on NIH RePORTER →