MULTICENTER, RANDOMIZED TRIAL OF DSRS VERSUS TIPS

$0M01FY2000RRNIH

University Of Wisconsin Madison, Madison WI

Investigators

Linked publications & trials

Paper 36946148 Paper 36940238 Paper 36066606 Paper 33471392 Paper 33252918 Paper 32795586 Paper 30160050 Paper 29251951 Paper 29025889 Paper 28862877 Paper 28125291 Paper 27613925 Paper 27609657 Paper 27489874 Paper 27061252 Paper 27001469 Paper 26227019 Paper 26012360 Paper 25979524 Paper 25918834 Paper 25783161 Paper 25744958 Paper 25485413 Paper 25384069 Paper 25360868 Paper 25091879 Paper 24952994 Paper 24835502 Paper 24711627 Paper 24642450 Paper 24589344 Paper 24556849 Paper 24529411 Paper 24498897 Paper 24364404 Paper 24332222 Paper 24209888 Paper 24187656 Paper 24142237 Paper 24084071 Paper 24050723 Paper 23975881 Paper 23954071 Paper 23855693 Paper 23844029 Paper 23780705 Paper 23669872 Paper 23669301 Paper 23632943 Paper 23612440 Paper 23541324 Paper 23537892 Paper 23508266 Paper 23414537 Paper 23410621 Paper 23341886 Paper 23331564 Paper 23297788 Paper 23287844 Paper 23181791 Paper 23169798 Paper 23041173 Paper 23040888 Paper 22995766 Paper 22963593 Paper 22865499 Paper 22832325 Paper 22818728 Paper 22766097 Paper 22750539 Paper 22735035 Paper 22694930 Paper 22642839 Paper 22588883 Paper 22554704 Paper 22321809 Paper 22241742 Paper 22236729 Paper 22227382 Paper 22180577 Paper 22160762 Paper 22140356 Paper 22103958 Paper 22102290 Paper 22095547 Paper 22070912 Paper 21991891 Paper 21960534 Paper 21878241 Paper 21798578 Paper 21792658 Paper 21699476 Paper 21572527 Paper 21496892 Paper 21441381 Paper 21416234 Paper 21397937 Paper 21373381 Paper 21347742 Paper 21335259

Abstract

This multi-center prospective, randomized clinical trial will compare the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding. The health relatedness is to define the relative merits of these two treatments with respect to morbidity, mortality and cost management. The hypothesis to be tested is that TIPS will have a significantly higher rebleeding rate and incidence of encephalopathy than DSRS. Uncontrolled studies show a variceal rebleeding rate of 20 percent after TIPS compared to 5 percent after DSRS, and an encephalopathy incidence of 30 percent after TIPS compared to 14 percent after DSRS. In this study, Childs Class A and B Cirrhotic patients with variceal bleeding which cannot be managed by endoscopy will be randomized to TIPS or DSRS.

View original record on NIH RePORTER →