GENETICS OF TYPE II DIABETES MELLITUS AND OBESITY

$0M01FY2000RRNIH

Johns Hopkins University, Baltimore MD

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Abstract

The Old Order Amish of Lancaster County, Pennsylvania, initially numbered in the hundreds, and are now a population of over 30,000. This population is a well-defined, genetically homogeneous Caucasian population with very large sibships, a high degree of consanguinity, and well-documented genealogies. The goal of this study is to recruit and phenotypically characterize large multiplex pedigrees with noninsulin-dependent diabetes mellitus (NIDDM) for a genome-wide search for susceptibility genes for this heterogeneous and polygenic disorder.

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