PHARMACOKINETICS OF SR45023A 7 DAY ADMINISTRATION CYCLE

$0M01FY2000RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

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Abstract

The purpose of this study is to determine the maximum tolerated dose of SR-45023A, a novel diphosphonate compound representing a new class of cytotoxic agents that activate the nuclear receptor, farnasoid X. Additionally the study will determine the quantitative and qualitative toxicities of the drug, assess its plasma pharmacokinetics when given once weekly, and document any anti-tumor activity.

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