PHARMACOKINETIC TRIAL OF WEEKLY DOCETAXEL IN SOLID TUMOR

$0M01FY2000RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

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Abstract

Docetaxel, a semisynthetic member of the taxoid family, promotes and stablilizes microtubules and thus inhibits cellular replications. In addition to evaluating the pharmacokinetics of the study drug, the protocol proposes to determine baseline alpha-acid glycoprotein levels and CYP3A4 activity and evaluate whether these levels are predictive for interpatient differences in toxicity and pharmacokinetics.

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