COL 3 28 DAY ORAL DOSING CYCLE IN ADVANCED SOLID TUMORS

$0M01FY2000RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

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Abstract

The study substance, Col-3, is a non-antibiotic tetracycline that functions as a matrix metalloprotease inhibitor. Col-3 will be administered in a dose escalating design in order to determine the maximum tolerated dose, the safety, efficacy, pharmacokinetics and pharmacodynamics of the drug.

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