PHASE I/II STUDY OF CI 980 IN ADULTS WITH GLIOMA

$0M01FY2000RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

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Abstract

This study will investigate the effects of a novel anticancer agent in subjects with newly diagnosed malignant gliomas, a group of tumors which remains refractory to standard treatment approaches. The study drug inhibits microtubule formation thus disrupting tubulin polymerization. The phase I portion of the study will determine the maximum tolerated dose of the drug, and the phase II portion will determine the response rate.

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