EFFECT OF ANTIRESORPTIVES IN PATIENTS W/ PAGETS DISEASE

$16,409M01FY2000RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

Investigators

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Abstract

Paget's is a disorder of bone remodeling. The process is initiated by an increase in osteoclast mediated bone resorption followed by an abundance of new but abnormal bone formation. This study will determine the number of osteoclast precursors, the level of IL-6 and the presence or absence of measles virus nucleocapsid mRNA in the peripheral blood from patients with Paget's disease at the start of their scheduled treatment with the antiresorptive bisphosphonate alendronate and at the completion of the 6 month treatment. The number of osteoclast precursors and the IL-6 levels will be correlated with the activity of the disease as determined by the levels of serum and urine markers of bone resorption and formation.

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