THROMBOPOIETIN &G-CSF IN CHILD SOLID TUMORS

$0M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

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Abstract

Previous studies utilizing either rhGM-CSF or rhG-CSF have demonstrated reductions in days of neutropenia and alterations in the neutrophil nadir; however, many have been restricted by dose-limiting thrombocytopenia. We hypothesize that rhTPO + G-CSF will modulate both neutropenia and thrombocytopenia following myelosuppressive combination chemotherapy.

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