Immunogenicity and Structure of HIV-1 gp140 glycoprotei

$0Z01FY2004AINIH

Niaid Extramural Activities

Investigators

Linked publications & trials

Paper 19696434 Paper 19287373 Paper 19008380 Paper 19004960 Paper 18922865 Paper 18833294 Paper 18284327 Paper 18197170 Paper 16621193 Paper 16415019 Paper 16103142 Paper 16014956 Paper 15661147 Paper 15582651 Paper 14985706

Abstract

In this study, we have produced soluble versions of Env glycoproteins derived from a primary isolate stabilized by heterologous trimerization motifs (foldon or GDN4). We have tested these glycoproteins for immunogenicity in rabbits and guinea pigs. Breadth of neutralization indicate that these glycoproteins are interesting platforms for furthere modification to better elicit broadly neutralizing antibodies.

View original record on NIH RePORTER →