PATHOPHYSIOLOGY AND TREATMENT IN SICKLE CELL DISEASE--PEDIATRIC HYDROXYUREA

$25,799M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

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Abstract

Hydroxyurea therapy has been found to have a beneficial effect on fetal hemoglobin and red cell survival in sickle cell disease. The purpose of this study is to determine the efficacy of hydroxyurea on children with sickle cell disease and to determine the therapeutic dose and effects on growth.

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