PHARMACODYNAMICS OF BMS 204352 IN STABLE CEREBROVASCULAR DISEASE

$575M01FY2000RRNIH

Massachusetts General Hospital, Boston MA

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Abstract

This study will assess the pharmacokinetics of BMS-204352 in patients with stable cerebrovascular disease. It would also be important to determine whether BMS-204352 causes regional perfusion deficits in patients with stable cerebrovascular disease, as has been found for dipyridamole or acetazolamide. The present study will assess the effects of BMS-204352 on regional cerebral blood flow using positron emission tomography (PET) and MRI methodology.

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