PHASE I TRIAL OF COL 3 IN HIV RELATED KAPOSI'S SARCOMA

$0M01FY2000RRNIH

Beth Israel Deaconess Medical Center, Boston MA

Investigators

Linked publications & trials

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Abstract

The purpose of this study is to determine the safety and toxicity of Col-3 in patients with HIV related Kaposi's Sarcoma. The study will also evaluate the antitumor activity of col-3, evaluate the effects of col-3 on CD4 and CD8 cell counts and percentages as well as on viral load, charcterize the pharmacokinetics of Col-3, describe the relationship between tumor response and serum levels of VEGF and bFGF, evaluate the effect of Col-3 on serum levels of MMP-2 and MMP-9 and evaluate the effect of serum from Col-3 treated subjects in angiogenesis assays.

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