INSULIN RECEPTOR AND IRS-1 GENES AND THEIR RELATIONSHIP TO INSULIN ACTION IN VIVO

$0M01FY2000RRNIH

Beth Israel Deaconess Medical Center, Boston MA

Investigators

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Abstract

The goals of this study are to determine the biochemical function of the insulin receptor and IRS-1 in vitro and in vivo action in female patients with Type A syndrome of insulin resistance and to determine the sequence of the coding regions of the insulin receptor and IRS-1 genes in non-obese individuals with PCO having insulin resistance.

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