ACTG 343: THREE MAINTENANCE REGIMENS FOR HIV INFECTED SUBJECTS

$0M01FY2000RRNIH

Beth Israel Deaconess Medical Center, Boston MA

Investigators

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Abstract

This study will compare the proportion of subjects who sustain suppression of plasma HIV RNA to undetectable levels among the three regimens during the maintenance phase; evaluate the proportion of subjects who exhibit no resumption of HIV replication after therapy is withdrawn; to evaluate CD4 and HIV RNA levels at baseline and CD4 cell counts at time of randomization to the maintenance phase as a predictor of successful maintenance therapy; to evaluate the drug resistance of breakthrough isolates; and to evaluate kinetics of HIV RNA and proviral DNA doubling in subjects in whom viral replication increases after withdrawal of therapy.

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