NEUROCHEMICAL MECHANISMS OF ANTICONVULSANT EFFECT OF VAG

$0M01FY2000RRNIH

University Of New Mexico, Albuquerque NM

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Abstract

This study is designed to study the neruochemical substrates of the anticonvulsant effect of VNS in patients with partial-onset epilepsy. 1H-MRS will be used to determine local tissue concentrations of NAA, cho,and Cr in the hippocampus and the insular cortex before, and 2 months and 6 months after the start of VNS. Values obtained before and after the start of VNS metabolic/neurochemical systems of the brain.

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