EFFECTS OF IMMUNOTOXIC XENOBIOTICS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES

$22,433M01FY2000RRNIH

University Of New Mexico, Albuquerque NM

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Abstract

The purpose of this study is to examine the effects of various environmental agents on human peripheral blood leukocytes (HPBL) following in vitro exposures. Three chemical classes of environmental pollutants will be examined, including heavy metals (Pb2+ and Cd2+), polycyclic aromatic hydrocarbons (benzo(a)pyrene), and polychlorinated biphenyls (PCBs). These agents are all immunsuppressive when given to animals or when human cells are exposed in vitro. The overall purpose is to develop biomarkers for immunotoxicity using flow cytometry.

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